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9+ hour, 39+ min ago  (140+ words) Critical Path Institute Launches 'One to Millions' to Reshape the Future of Individualized Medicine at Global Scale'PA Media C-Path's New Paper in Nature Reviews Drug Discovery Highlights How to Maximize the Regulatory Impact of Consortium-Based Projects C-Path's Disease Modeling Coalition…...

7+ hour, 31+ min ago  (336+ words) New magnetic bead-based DNA kit from INTEGRA streamlines genomic DNA extraction with automation, high purity, and reduced hands-on time. INTEGRA Biosciences has launched the Clean Blood & Tissue DNA Kit, a magnetic bead-based solution designed to simplify genomic DNA (gDNA) extraction…...

6+ hour, 47+ min ago  (255+ words) Credit: Alonda Hines/ORNL, U.S. Dept. of Energy Jennifer Morrell-Falvey, a senior staff scientist at the Department of Energy's Oak Ridge National Laboratory, has been elected as a fellow of the'American Association for the Advancement of Science, or AAAS, one of…...

11+ hour, 28+ min ago  (264+ words) A spider that glows? Scientists have successfully engineered a spider to produce silk that shines in bright red fluorescence. In a world-first experiment, scientists in Germany have used CRISPR-Cas9 to create genetically modified spiders that spin red, fluorescent silk. The…...

20+ hour, 9+ min ago  (370+ words) Sperm whales have been recorded headbutting each other for the first time, confirming long-standing accounts from 19th century whaling narratives. Researchers from the University of St Andrews documented this behaviour using drone technology during field studies conducted between 2020 and 2022 in the…...

1+ day, 8+ hour ago  (470+ words) In their landmark 1961 paper of the lac operon, Nobel laureates Fran'ois Jacob and Jacques Monod speculated that RNA might control gene activity in bacteria through base-pairing interactions. But once protein transcription factors were discovered, the idea was tossed aside. Sixty…...

1+ day, 16+ hour ago  (376+ words) Why validate after protein purification When combined with the Amersham" ImageQuant" 800 Western blot imaging system and ImageQuant" TL analysis software, researchers can quickly perform quantitative densitometry to determine whether the purification was satisfactory or whether further optimization is needed. This…...

1+ day, 11+ hour ago  (715+ words) UCSF researchers capture the first atomic-level snapshots of the cold-sensing protein in action. image:A three-dimensional reconstruction of TRPM8 embedded in a cell membrane. Four TRPM8 proteins are assembled as a functional ion channel. The TRPM8 proteins are shown in light blue and…...

1+ day, 11+ hour ago  (1130+ words) Summary: For the first time, researchers have captured the molecular "dance" of TRPM8, the protein in our nerve cells responsible for sensing cold and the cooling tingle of menthol. The study uses a combination of flash-freezing (cryo-EM) and real-time motion tracking…...

1+ day, 12+ hour ago  (748+ words) When you reach into a bucket of ice, step outside on a snowy day, or feel the tingle of menthol toothpaste, a protein in your nerve cells called TRPM8 springs into action, opening like a tiny gate to send a "cold…...