Scientists Decode the Full Genome of the Ocean-Wandering Trindade Petrel
Researchers have assembled a 1.25-gigabase, long-read reference genome for the Trindade petrel, a threatened seabird known for hybridisation and split breeding seasons.
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SWI/SNF complexes shape 3D chromatin architecture through CTCF and cohesin
Nature (2026) Cite this article As stronger CTCF sites drive loop extrusion48, we ranked CTCF ChIP–seq peaks by baseline WT intensity and observed that stronger peaks gained greater accessibility in ARID1A-deficient cells than…
Pseudotime Simulates Disease Progression from Case-Control RNA-Seq
The resulting diagrams look like trees. Scientists call branches healthy or diseased based on their expression of known markers. This, in turn, places each cell along the health to disease trajectory, exposing sequential gene…
Why Are Octopuses So Smart? The Answer May Lie in How Their DNA Folds
The extraordinary intelligence of octopuses, squid, and cuttlefish may be linked to more than just their genes. Octopuses can solve problems, squid can rapidly change their appearance, and cuttlefish display remarkably…
Accurate long-read de novo assembly evaluation with Inspector
Zechen Chong, M.D.Zechen Chong, Ph.D., assistant professor in the Department of Genetics, is the latest winner of the Heersink School of Medicine’s Featured Discovery. This initiative celebrates important research from Heersink…
Mitochondrial Enzyme FDXR Emerges as Prognostic Marker in Leukemia Linked to HTLV-1
Researchers report that the mitochondrial enzyme FDXR is upregulated in HTLV-1-infected cells, tracks disease severity and prognosis in adult T-cell leukemia/lymphoma, and predicts sensitivity to fluorouracil and bleomycin in laboratory tests.
Secretion of SOD1 Mutant Proteins Tied to ALS
In amyotrophic lateral sclerosis (ALS), motor neurons in the spinal cord and central nervous system die off for unknown reasons, causing creeping paralysis and, eventually, death. Mutations in the ... In amyotrophic lateral…
Dysregulated purine metabolism produces profound neurodevelopmental defects
Cell metabolism is often thought of as the process of breaking down sugars to create energy, but the process also involves all the biosynthetic reactions necessary to sustain life. One of these ... Dysregulated purine metabolism produces profound neurodevelopmental defects Cell metabolism is often thought of as the process of breaking down sugars to create energy, but the process also involves all the biosynthetic reactions necessary to sustain life. One of these biosynthetic processes is nucleotide synthesis. Nucleotide synthesis can be divided into two major arms: purine and pyrimidine biosynthesis. Both arms are important for DNA and RNA synthesis, but purine nucleotides are unique because they act as a form of cellular currency, powering other cellular reactions as GTP and ATP. Inosine Monophosphate Dehydrogenase 2 (IMPDH2) is an enzyme that powers the first committed step of GTP…
Selective Vulnerability News: RORB Neurons Are First Victims of Tangles
“The identification and molecular characterization of selectively vulnerable neurons in AD is a very important contribution,” commented Hansruedi Mathys of the Massachusetts Institute of Technology. “This work will undoubtedly…
Scientists reverse Parkinson’s symptoms in mice — Could humans be next?
Groundbreaking research by the University of Sydney has identified a new brain protein involved in the development of Parkinson's disease and a way to modify it, paving the way for future treatments for the disease. Parkinson's…
Do Spiders Dream? Scientists Discover Their Sleep Is Strangely Similar to Ours
New experiments reveal REM-like sleep in spiders and a surprising need to repay lost sleep. What could a spider dream about? For Portia fimbriata, a tiny predator that hunts other spiders, perhaps its the next kill. At night…
Sorting Progranulin With Sortilin—New Clues to FTLD Pathology
Progranulin, a raw form of granulin (GRN), landed center stage of neurodegeneration research four years ago (see ARF related news story), when scientists discovered that loss-of-function mutations in ... Progranulin, a raw form…
Bacterial Shikimate Network Offers Dual Targets for Antibiotic and Antivirulence Drugs
A new open-access review proposes attacking both the upstream enzymes of the bacterial shikimate pathway and the chorismate-derived siderophore systems that drive virulence as a combined antibacterial and antivirulence strategy.
Eukaryotes’ closest relatives are internally simple syntrophic peptidotrophic archaea
Nature (2026) Cite this article To evaluate the temperature range for growth, a pure co-culture of HC1 and a tri-culture of SC1 were incubated at a range of 10 °C to 45 °C or 10 °C to 50 °C. All incubations were performed in…
Tiny molecules unlock big gains in soil health
Framework of how lignin-derived (LSM) and humus-derived (HSM) small molecule addition promotes the formation of newly formed mineral-associated organic matter (13C-MAOM) from 13C-labeled straw in ... Tiny molecules unlock big…
Fungal Networks May Spread Antibiotic Resistance in Composting Manure
"Fungi are more than just decomposers in composting systems. Our findings suggest that they also help create microbial connections that allow antibiotic resistance genes to persist and potentially spread," said Jing Yuan…